Objectives
- Provide expert multidisciplinary care for head and neck cancer patients
- Increase access to novel treatment strategies for patients with all stages of head and neck cancer
- Total EGFR blockade
- Immunotherapy
- Radiation priming IIT - Build chemoprevention and behavioral health programs to better serve catchment area, provide foundation for research into HNC prevention
Yale Head and Neck Cancer Specialized Program of Research Excellence Aims:
- Aim 1: To overcome resistance to EGFR inhibition in HNSCC by targeting active conformations of ErbB family members;
- Aim 2: To advance rational synthetic lethal combination therapy to the clinic in HPV-negative HNSCC;
- Aim 3: To advance combination demethylating therapy with immune checkpoint inhibition to the clinic for HPV-mediated HNSCC, with mechanistic studies and characterization of immune response;
- Aim 4: To bolster the foundation for HNSCC research through our Administrative, Biospecimen and Biostatistics/Bioinformatics cores, to engage institutional resources and the wider SPORE community;
- Aim 5: To advance new research and to foster the next generation of HNSCC translational researchers through a Developmental Research Program, a Career Enhancement Program, and interaction and collaboration with the wider SPORE and HNSCC research communities.
SPORE Monthly Meetings: Tuesday @ 1:15pm - 2:15pm