2017
Proteotyping Gene Dosage Effects in Genetic Diseases
Liu Y, Aebersold R. Proteotyping Gene Dosage Effects in Genetic Diseases. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.926.3.Peer-Reviewed Original ResearchGene dosage imbalanceCopy number variationsProtein degradationDosage imbalanceGenetic diseasesSubstantial post-transcriptional regulationHeteromeric protein complexesDivergent expression levelsPost-transcriptional regulationCorresponding protein abundanceDNA copy number variationsComponents of pathwaysTurnover analysisPatient-derived induced pluripotent stem cellsInduced pluripotent stem cellsSWATH mass spectrometryPluripotent stem cellsGene dosage effectProtein turnover ratesPluripotent stateTranscript profilingSILAC experimentsProtein complexesTranslational regulationRNA-seq
2016
The interdependence of transcript and protein abundance: new data–new complexities
Liu Y, Aebersold R. The interdependence of transcript and protein abundance: new data–new complexities. Molecular Systems Biology 2016, 12: msb156720. PMID: 26792872, PMCID: PMC4731012, DOI: 10.15252/msb.20156720.Peer-Reviewed Original ResearchProtein abundanceGene expression controlER stress responseExpression controlTranslational regulationEndoplasmic reticulum stressMammalian cellsTranscriptomic changesStress responseReticulum stressProtein levelsTranscriptsAbundanceCellsRelative contributionRecent reportsRegulationRecent workChallenging questions
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